ALPROSTADIL (PROSTAGLANDIN E1)
Compound Overview
Alprostadil is a synthetic form of Prostaglandin E1 (PGE1), a naturally occurring lipid-derived signaling molecule belonging to the eicosanoid family. Although commonly grouped with research peptides in laboratory catalogs, Alprostadil is chemically a prostaglandin rather than a peptide. It is synthesized from arachidonic acid and functions through selective activation of prostaglandin E (EP) receptors, making it an important investigational compound for studying cellular signaling, vascular physiology, smooth muscle biology, and inflammatory mediator pathways.
Researchers have extensively investigated Alprostadil for its interactions with EP receptor subtypes (EP1–EP4), cyclic adenosine monophosphate (cAMP) signaling, vascular smooth muscle regulation, endothelial biology, platelet physiology, and intracellular second messenger systems. Experimental studies continue to explore its biochemical properties, receptor pharmacology, and molecular mechanisms in controlled laboratory models.
As an investigational research compound, Alprostadil supports laboratory studies involving vascular biology, molecular pharmacology, cellular signaling, prostaglandin metabolism, and structure-activity relationships.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Chemical Name | Prostaglandin E1 (Alprostadil) |
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.48 g/mol |
| CAS Number | 745-65-3 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture, heat, oxygen, and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of ALPROSTADIL (PROSTAGLANDIN E1) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve compound stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized material from moisture, excessive heat, oxygen, and direct light, as prostaglandins are susceptible to degradation under improper storage conditions. Following reconstitution, avoid repeated freeze-thaw cycles. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid Receptors: Structures, Properties, and Functions. Physiological Reviews.
- Smith WL, Urade Y, Jakobsson PJ. Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis. Chemical Reviews.
- Funk CD. Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology. Science.
- Ricciotti E, FitzGerald GA. Prostaglandins and Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology.
Compare with related compounds
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| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| ALPROSTADIL (PROSTAGLANDIN E1) | 99% | 354.48 g/mol | 745-65-3 |
| MT-II (MELANOTAN II) | 99% | 1,024.2 g/mol | 121062-08-6 |
| MT-I (MELANOTAN I / AFAMELANOTIDE) | 99% | 1,646.84 g/mol | 75921-69-6 |
| PT-141 (BREMELANOTIDE) | 99% | 1,025.18 g/mol | 189691-06-3 |
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