CAGRILINTIDE
Compound Overview
Cagrilintide is a synthetic, long-acting amylin analog engineered to mimic the biological activity of endogenous human amylin while exhibiting enhanced stability and an extended duration of action. Structurally modified through amino acid substitutions and lipidation technology, Cagrilintide demonstrates prolonged pharmacokinetic properties, making it an important investigational peptide for studying amylin receptor pharmacology and metabolic signaling.
Researchers have extensively investigated Cagrilintide for its selective interactions with amylin receptors, which are complexes formed by the calcitonin receptor (CTR) and receptor activity-modifying proteins (RAMPs). Experimental studies have examined its role in cellular signaling, energy homeostasis, neuroendocrine regulation, gastric physiology, and metabolic pathway modulation. Cagrilintide has also become a valuable research tool for investigating peptide engineering, receptor biology, and long-acting peptide design.
As an investigational peptide, Cagrilintide supports laboratory research involving endocrinology, metabolic physiology, receptor pharmacology, peptide chemistry, and structure-activity relationship studies.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Sequence | Synthetic long-acting amylin analog |
| Molecular Formula | C225H348N48O68 |
| Molecular Weight | Approximately 4,183.8 g/mol |
| CAS Number | 1415456-99-3 |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of CAGRILINTIDE is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For extended laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide stability and biological integrity. Allow the vial to equilibrate to room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic laboratory techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Lau DCW, Erichsen L, Francisco AM, et al. Once-Weekly Cagrilintide for Weight Management: A Randomized, Controlled Phase 2 Trial. The Lancet.
- Kapitza C, Dahl K, Jacobsen JB, Axelsen MB. Effects of the Long-Acting Amylin Analog Cagrilintide on Pharmacokinetics and Pharmacodynamics. Diabetes, Obesity and Metabolism.
- Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Therapeutic Potential. Pharmacological Reviews.
- Coester HV, et al. Long-Acting Amylin Analogs and Their Role in Metabolic Research. Frontiers in Endocrinology.
Compare with related compounds
Other compounds researchers commonly browse alongside CAGRILINTIDE in Metabolic & Weight Research.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| CAGRILINTIDE | 99% | Approximately 4,183.8 g/mol | 1415456-99-3 |
| RETATRUTIDE | 99% | Approximately 4,731.33 g/mol | 2381089-83-2 |
| AOD-9604 | 99% | 1,815.08 g/mol | 221231-10-3 |
| MAZDUTIDE | 99% | Approximately 4.5 kDa | Not Assigned |
| SURVODUTIDE | 99% | Approximately 4.6 kDa | Not Assigned |
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