PT-141 (BREMELANOTIDE)
Compound Overview
PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide derived from the melanocortin peptide family. It is structurally related to Melanotan II (MT-II) and functions primarily as a melanocortin receptor agonist, exhibiting activity at several melanocortin receptor subtypes, particularly MC4R and MC1R. Its receptor selectivity has made PT-141 an important investigational peptide for studying melanocortin signaling, neuroendocrine physiology, and receptor pharmacology.
Researchers continue to investigate PT-141 in experimental models to better understand melanocortin receptor activation, intracellular signaling pathways, peptide-receptor interactions, and central nervous system mechanisms associated with melanocortin biology. Its well-defined pharmacological profile has established PT-141 as a valuable tool in peptide science and receptor biology.
As an investigational research peptide, PT-141 supports studies involving receptor selectivity, peptide pharmacokinetics, molecular signaling, and structure-activity relationships within the melanocortin receptor system.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1,025.18 g/mol |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended laboratory storage, maintain at −20°C or below. Protect from moisture and light. |
| CAS Number | 189691-06-3 |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of PT-141 (BREMELANOTIDE) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For long-term laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct light. Avoid repeated freeze-thaw cycles following reconstitution, as these may affect peptide integrity. Allow the vial to reach room temperature before opening to minimize condensation, and always use sterile laboratory equipment together with appropriate aseptic handling techniques. This product is intended for use only by qualified research personnel operating in controlled laboratory environments.
Selected Scientific Literature
- Martin WJ, et al. Behavioral and Pharmacological Characterization of Bremelanotide (PT-141), a Melanocortin Receptor Agonist. Journal of Pharmacology and Experimental Therapeutics.
- Hadley ME, Dorr RT. Melanocortin Peptide Therapeutics: Historical Perspectives and Future Directions. Peptides.
- Hruby VJ, Cai M, Nyberg J, et al. Design, Synthesis, and Biological Evaluation of Melanocortin Receptor Ligands. Current Topics in Medicinal Chemistry.
- Cone RD. Studies on the Physiological Functions of the Melanocortin System. Nature Reviews Endocrinology.
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| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| PT-141 (BREMELANOTIDE) | 99% | 1,025.18 g/mol | 189691-06-3 |
| MT-II (MELANOTAN II) | 99% | 1,024.2 g/mol | 121062-08-6 |
| MT-I (MELANOTAN I / AFAMELANOTIDE) | 99% | 1,646.84 g/mol | 75921-69-6 |
| ALPROSTADIL (PROSTAGLANDIN E1) | 99% | 354.48 g/mol | 745-65-3 |
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