TB-500 (THYMOSIN BETA-4 FRAGMENT)
Compound Overview
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring peptide found in many mammalian tissues. While Thymosin Beta-4 is a 43-amino acid protein involved in cellular processes, TB-500 is a shorter synthetic fragment developed for laboratory investigation of its biological activity and peptide pharmacology.
Researchers continue to investigate TB-500 in experimental models to better understand its role in actin dynamics, cellular migration, angiogenesis, cytoskeletal organization, and tissue physiology. Due to its interaction with actin-binding pathways, TB-500 has become a valuable investigational peptide for studying cellular movement, wound biology, extracellular matrix remodeling, and peptide-mediated signaling mechanisms.
As an experimental research compound, TB-500 provides scientists with a useful model for investigating peptide structure-function relationships, intracellular signaling pathways, pharmacokinetics, and molecular mechanisms associated with tissue homeostasis and cellular organization.
Research Applications
Research applications are presented for educational and informational purposes only and do not imply approved therapeutic uses.
Product Specifications
| Purity | 99% |
| Appearance | White to Off-White Lyophilized Powder |
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | 4,963.44 g/mol |
| Storage | Store refrigerated at 2–8°C (36–46°F). For extended storage, maintain at −20°C or below. Protect from moisture and direct light. |
| CAS Number | 77591-33-4 (Thymosin Beta-4; TB-500 itself does not have a universally recognized CAS assignment, and suppliers often reference the parent peptide.) |
| Research Grade | Laboratory Research Use Only |
Available Sizes
Pricing: Inquire — contact our team for current pricing and availability.
Product Documentation
Every batch of TB-500 (THYMOSIN BETA-4 FRAGMENT) is independently tested and assigned its own lot number. When you request documentation, include the product name and lot number printed on your vial so we can send the COA, HPLC, and MS data specific to the batch in your hand — not a generic reference sample. Request documentation →
Laboratory Handling
Store refrigerated immediately upon receipt to preserve peptide stability. For long-term laboratory storage, freezing at −20°C or below is recommended. Protect the lyophilized peptide from moisture, excessive heat, and direct sunlight. Avoid repeated freeze-thaw cycles following reconstitution, as these may reduce peptide integrity. Allow the vial to reach room temperature before opening to minimize condensation, and use sterile laboratory equipment together with appropriate aseptic handling techniques. This product is intended for use only by qualified research personnel in controlled laboratory environments.
Selected Scientific Literature
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: Actin-Sequestering Protein and Regulator of Tissue Repair. Annals of the New York Academy of Sciences.
- Malinda KM, Sidhu GS, Mani H, et al. Thymosin β4 Accelerates Wound Healing. Journal of Investigative Dermatology.
- Huff T, Müller CSG, Otto AM, et al. β-Thymosins, Small Acidic Peptides with Multiple Functions. International Journal of Biochemistry & Cell Biology.
- Smart N, Risebro CA, Melville AAD, et al. Thymosin β4 Induces Adult Epicardial Progenitor Mobilisation and Neovascularisation. Nature.
Compare with related compounds
Other compounds researchers commonly browse alongside TB-500 (THYMOSIN BETA-4 FRAGMENT) in Healing & Recovery.
| Compound | Purity | Molecular Weight | CAS Number |
|---|---|---|---|
| TB-500 (THYMOSIN BETA-4 FRAGMENT) | 99% | 4,963.44 g/mol | 77591-33-4 (Thymosin Beta-4; TB-500 itself does not have a universally recognized CAS assignment, and suppliers often reference the parent peptide.) |
| BPC-157 | 99% | 1,419.53 g/mol | 137525-51-0 |
| BPC-157 + TB-500 BLEND | 99% (Each Peptide) | — | Blend – Not Applicable |
| GHK-Cu (COPPER TRIPEPTIDE-1) | 99% | 403.93 g/mol | 89030-95-5 |
| Glow Blend (Cu50 + TB10 + BPC10) | 99% (Each Peptide Component) | 70 mg | — |
Need a Certificate of Analysis?
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